KP-457

KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC50s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively.

1365803-52-6

12352005

H302, H315, H319, H335

MMP

Reference compound

Metabolic Enzyme/Protease

COVID-19-immunoregulation

Cardiovascular Disease

https://www.medchemexpress.com/KP-457.html

99.18

DMSO : 125 mg/mL (ultrasonic)

CS(=O)(NCC1=CC=C(C(N(C=O)O)CS(=O)(C2=CC=C(OCC#CC)C=C2)=O)C=C1)=O

C21H24N2O7S2

480.55

H302, H315, H319, H335

[1]Hirata S, et al. Selective Inhibition of ADAM17 Efficiently Mediates Glycoprotein Ibα Retention During Ex Vivo Generation of Human Induced Pluripotent Stem Cell-Derived Platelets. Stem Cells Transl Med. 2017 Mar;6 (3) :720-730.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-110397/KP-457-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported

ADAM10; ADAM17; MMP-13; MMP-14; MMP-17; MMP-2; MMP-3; MMP-8; MMP-9